"Amber" drinks in the regulation of the functional state of the human body
https://doi.org/10.46845/1997-3071-2025-76-64-73
Abstract
Baltic amber is a symbol of the Kaliningrad region and the whole Russia. The use of non-liquid (fine-dispersed) fractions of amber is currently not included in the technological schemes of the Kaliningrad Amber Plant. This study proposes the application of one of the components of amber waste, namely, succinic acid, which constitutes about 10% of the weight of the waste. Its annual production can reach two tons. Along with the well-known properties of succinic acid as an energy substrate, antioxidant, a substance involved in diabetes prevention, and a contributor to the formation of the body’s radio-resistance; it has also been found to have the potential for transformation into gamma-aminobutyric acid, which belongs to the group of adaptogens and has non-pharmacological effects on the human body. According to current sanitary regulations, succinic acid can be included in beverages. This work presents a scheme and discusses the mechanism of possible transformation of succinic acid into gamma-aminobutyric acid in the Roberts cycle (aminobutyrate shunt). The developed technological scheme for producing a dry product, enriched not only with succinic acid but also with essential trace elements (magnesium, calcium, and potassium), can be used to reduce transportation costs, while the beverage itself can be bottled directly into consumer containers in the form of aqueous solutions obtained from the dry substance. It is assumed that this sparkling drink will also become an attribute of celebrations and will be used to create a festive atmosphere. This research is relevant against the backdrop of growing interest in a healthy lifestyle and the need to reduce the negative consequences associated with alcoholism, drug dependence, and the use of neuroleptics to improve the overall health of the body.
About the Authors
V. D. LemeshkoRussian Federation
Valeriya D. Lemeshko – student
Kaliningrad
B. Yu. Vorotnikov
Russian Federation
Boris Yu. Vorotnikov – Ph.D. in Engineering, Head of the Department of Chemistry
Kaliningrad
References
1. Kondrashova M. N. Regulyatsiya yantarnoy kislotoy energetitsheskogo obespeсheniya i funktsional'nogo sostoyaniya tkani [Regulation of the energy supply and functional state of the tissue by succinic acid]. Pushchino, Meditsina Publ., 1976, 150 р.
2. Nutt D., Tyacke Y., Robin Y. Functional Alternatives to Alcohol. Nutrients. 2022. N 1. P. 1–5.
3. Turgunov M. A. Preparaty gruppy neyroleptikov v praktike dokazatel'noy meditsiny [Drugs of the group of neuroleptics in the practice of evidence-based medicine]. Ekonomika i sotsium, 2022, no. 3, pp. 3–4.
4. Yantar': znaniya i tekhnologii: sbornik nauсhnykh trudov [Amber: knowledge and technology: collection of scientific papers]. Pod red. B. Yu. Vorotnikova. Kaliningrad, 2008, 153 p.
5. Sem'yanov A. V. GAMK-ergitsheskoe tormozhenie v TSNS: tipy GAMK-retseptorov i mekhanizmy tonitsheskogo GAMK-oposredovannogo tormoznogo deystviya [GABA-ERGIC inhibition in the central nervous system: types of GABA receptors and mechanisms of tonic GABA-mediated inhibitory action]. Neyrofiziologiya, 2002, no. 1, pр. 2–9.
6. Garust Yu. V. Yantarnaya kislota i vozmozhnosti ee primeneniya pri khroniсheskikh dermatozakh [Succinic acid and the possibilities of its use in chronic dermatoses]. Torsuevskie chteniya, 2020, no. 2, pp. 3–9.
7. Zinkevitsh D. D., Lebedev A. N., Degtyaryova E. I., Petrovskaya T. A. Bakteritsidnye svoystva yantarnoy kisloty v otnoshenii zolotistogo stafilokokka [Bactericidal properties of succinic acid against Staphylococcus aureus]. Materialy Mezhdunarodnoy nauchno-prakticheskoy konferentsii [Prospects of the International Scientific and Practical Conference]. Kursk, 2022, pр. 73–75.
8. Evsenina M. V., Shimanova E. K. Perspektivy primeneniya yantarnoy kisloty [Prospects for the use of succinic acid]. Materialy XV mezhdunarodnoy nauchno prakticheskoy konferentsii, posvyashchennoy 100-letiyu zasluzhennogo agronoma BSSR, professora BGSHA A. M. Bogomolova [Prospects of the XV International scientific and practical conference dedicated to the 100th anniversary of the Honored agronomist of the BSSR, Professor of the BSSA A. M. Bogomolov]. Gorki, 2020, pp. 115-118.
9. Khlebalina A. S., Lunegov A. M. Yantarnaya kislota kak dopolnitel'nyy element kompozitsionnykh preparatov [Succinic acid as an additional element of composite preparations]. Materialy Mezhdunarodnoy nauchno-prakticheskoy konferentsii, posvyashchennoy 100-letiyu so dnya rozhdeniya professora V. V. Rudakova [Prospects of the International scientific and practical conference dedicated to the 100th anniversary of the professor V. V. Rudakov]. Saint-Petersburg, 2023, pp. 278–279.
10. Smirnov A. V., Nesterova O. B., Golubev R. V. Yantarnaya kislota i ee pri menenie v meditsine. Chast' I. Yantarnaya kislota: metabolit i regulyator metabolizma organizma cheloveka [Succinic acid and its use in medicine. Part I. Succinic acid: a meta-pain and a regulator of the human body's metabolism]. Nefrologiya, 2014, no. 2, pp. 1–4.
11. Ben-Ari Y., Tseeb V., Raggozzino D. Gamma-aminobutyric acid (GABA): a fast excitatory transmitter which may regulate the development of hippocampal neurons in early postnatal life. Progress in Brain Research. 1994. N 3, P. 261–273.
12. Shcherbakova T. N., Ozerova P. A. Izuchenie protivootechnogo deystviya fenibuta i novykh proizvodnykh GAMK [Study of the decongestant effect of phenibut and new GABA derivatives]. Farmatsiya i farmakologiya, 2015, no. 3, pp. 72–74.
13. Kovalenko A. L., Belyakova N. A., Romantsov M. G. Farmakologicheskaya aktivnost' yantarnoy kisloty i ee lekarstvennye formy [Pharmacological activity of succinic acid and its dosage forms]. Vrach, 2000, no. 4, pp. 2–5.
14. Devoyno V. K, Il'yuchenok R. Yu. Neyromediatornye sistemy v psikho-neyroimmunomodulyatsii: dofamin, serotonin, GAMK, neyropeptidy [Neurotransmitter systems in psychoneuroimmunomodulation: dopamine, serotonin, GABA, neuropeptides]. Novosibirsk, TSERIS Publ., 1993, 240 p.
15. Ariza A., Deen P., Robben J., Lausanne M. The succinate receptor as a novel therapeutic target for oxidative and metabolic stress-related conditions. Front Endocrinol. 2021. N 3, P. 1–8.
16. Savin G. A., Sitnikova A. A., Biryukova E. G. Sintez atsilamidnykh proizvodnykh yantarnoy kisloty [Synthesis of acylamide derivatives of succinic acid]. Grani poznaniya, 2022, no. 3 (80), pp. 64–67.
17. Kuznetsova V. A., Naumenko O. A. Polozhitel'noe vliyanie yantarnoy kisloty na protsessy biokhimicheskoy adaptatsii rasteniy [The positive effect of succinic acid on the processes of biochemical adaptation of plants]. Materialy II Vserossiyskoy nauchno-prakticheskoy konferentsii s mezhdunarodnym uchastiem "Molodye uchenye - nauke i praktike XXI veka" [Prospects of the II All-Russian scientific and practical conference with international participation "Young scientists – science and practice of the XXI century"]. Orenburg, 2023, pp. 226–229.
18. Vorotnikov B. Yu., Pritykina N. A., Tkachev I. M. Ispol'zovanie yantarnoy kisloty dlya polucheniya ovoshchnogo sousa "Yantarnyy chili" [The use of succinic acid for the production of vegetable sauce "Amber chili"]. Materialy XI Mezhdunarodnogo Baltiyskogo morskogo foruma [Prospects of the XI International Baltic Maritime Forum]. Kaliningrad, 2023, pp. 34–36.
Review
For citations:
Lemeshko V.D., Vorotnikov B.Yu. "Amber" drinks in the regulation of the functional state of the human body. KSTU News. 2025;(76):64-73. (In Russ.) https://doi.org/10.46845/1997-3071-2025-76-64-73